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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
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  • Calcium carbonate (also used to treat hypertension): This medication can cause a slight increase in blood pressure with some individuals reporting mild decreases in blood pressure of a few mmHg.This side effect typically goes away after a few hours, reducing to -0.5 mmHg if the dose is increased.
  • C.

    Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness. Here are the drug-food interactions to be aware of:

    1. : Though not a direct interaction, combining Cialis with Cialis+ alcohol can worsen side effects like headaches or increase heart rate in sensitive individuals.
    2. : While taking Cialis with a high-fat meal may delay its onset of action, consuming it alongside a high-fat meal may enhance their effectiveness.

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    Cialis 20 mg

    Tadalafil 5 mg

    Buy Cialis 10mg (Tadalafil 5mg)

    Cialis is used to treat male erectile dysfunction (ED) in men. In combination with sexual stimulation, it increases blood flow to the penis to help men get an erection. It belongs to a group of medicines known as phosphodiesterase type 5 (PDE 5) inhibitors.

    How to use Cialis 10mg

    The dosage of Cialis 10mg tablets will be as follows:

    Adults:Take one tablet about 30 minutes before sexual activity; this dose should last for up to 4 hours. Cialis works by helping to relax the smooth muscles in the penis and allow blood to flow into it when sexually stimulated. The effects of Cialis (Tadalafil 5mg) last for up to 36 hours. If the effect is not long-lasting or does not last longer than 4 hours, or no effect after 12 hours, Cialis 10mg should not be taken.

    Driving or using machines is not recommended

    Cialis is not supposed to be taken with nitrates, so nitrates are not absorbed and will help only with erectile dysfunction. Try not to take Cialis when you are taking nitrates. Nitrates are freely digested and are not absorbed by the body.

    Possible side effects of Cialis 10mg

    Erectile dysfunction:Cialis (Tadalafil 5mg) works about 50% of the time in the body. The other 50-60% of the time is due to an effect on blood flow to the penis; this usually goes away after sexual activity. For most men, the side effects of Cialis 5mg are mild. The most common are:

    • flushing
    • headache
    • indigestion
    • nausea
    • vomiting
    • hard contentedness

    If you experience difficulty achieving or maintaining an erection, Cialis may not be suitable. Try not to take the side effects of Cialis serious; take only what makes you effective and get back to normal sexual activity.

    Allergy

    If you have a known allergy to Cialis or any of the other ingredients of this medicine, avoid taking it.

    Use only as directed by your doctor.Do not use Cialis 5 mg if you have ever had an allergic reaction to any of the medicines described above.

    Cialis may reduce your blood pressure, so this medicine is not recommended for use in adults and children. Inform your doctor if you are pregnant or breastfeeding.

    If you accidentally get into any of the medicine,rinses andkillers described here. If the medicine does not seem to help, talk to your doctor. In addition, it is advised to inform your doctor if you are taking any other medicines, including herbal medicines. Tell your doctor if you are taking any of the following:

    • Nitroglycerin
    • other alpha-blockers
    • medicines containing alginic acid
    • some antibiotics including t PLUS doxazosin (minocycline and erythromycin)
    • medicines that relax the blood vessels in the penis
    • medicines that it is considered best to avoid while having sex

    Some general information about medicine. general information about medicine. general information about sex.

    Cialis 10mg side effects

    Most of the time, these side effects go away as your body adjusts to the medicine.

    Erectile Dysfunction

    Erection problems (impotence) are very common, particularly in men over 40.

    Most men occasionally fail to get or keep an erection. This is usually due to stress, tiredness, anxiety or drinking too much alcohol, and it’s nothing to worry about.

    If it happens more often, it may be caused by physical or emotional problems.

    Physical causes Possible cause Treatment Narrowing of penis blood vessels, high blood pressure, high cholesterol medicine to lower blood pressure, statins to lower cholesterol Hormone problems hormone replacement – for example, testosterone Side effects of prescribed medication change to medicine following discussion with GP You may also be asked to make lifestyle changes.

    Do lose weight if you’re overweight stop smoking eat a healthy diet exercise daily try to reduce stress and anxiety

    Don’t cycle for a while (if you cycle more than 3 hours a week) drink more than 14 units of alcohol a week

  • Side Effects

    Possible side effects

    Like all medicines, this medicine can cause side effects, although not everybody gets them. These effects are normally mild to moderate in nature.

    If you experience any of the following side effects stop using the medicine and seek medical help immediately:

    allergic reactions including rashes (frequency uncommon). chest pain – do not use nitrates but seek immediate medical assistance (frequency uncommon). priapism, a prolonged and possibly painful erection after taking CIALIS (frequency rare). If you have such an erection, which lasts continuously for more than 4 hours you should contact a doctor immediately. sudden loss of vision (frequency rare). Other side effects have been reported:

    Common (seen in 1 to 10 in every 100 patients)

    headache, back pain, muscle aches, pain in arms and legs, facial flushing, nasal congestion, and indigestion. Uncommon (seen in 1 to 10 in every 1,000 patients)

    dizziness, stomach ache, feeling sick, being sick (vomiting), reflux, blurred vision, eye pain, difficulty in breathing, presence of blood in urine, prolonged erection, pounding heartbeat sensation, a fast heart rate, high blood pressure, low blood pressure, nose bleeds, ringing in the ears, swelling of the hands, feet or ankles and feeling tired. Rare (seen in 1 to 10 in every 10,000 patients)

    fainting, seizures and passing memory loss, swelling of the eyelids, red eyes, sudden decrease or loss of hearing, hives (itchy red welts on the surface of the skin), penile bleeding, presence of blood in semen and increased sweating. Heart attack and stroke have also been reported rarely in men taking CIALIS. Most of these men had known heart problems before taking this medicine.

    Partial, temporary, or permanent decrease or loss of vision in one or both eyes has been rarely reported.

  • Authiliation Type Unapproved Drug Type Other

    The most common side effects of CIALIS are gastrointestinal (frequency rare), such as nausea, vomiting, abdominal pain, and diarrhea. Rare side effects are (frequency rare).

    See for further details.

    Now, you need to look at the following medicines: Drug types similar to this medicine

    This medicine (CIALIS) has been approved for use in England since October 2003.

    There are no similar medicines for heartburn
    Active IngredientStrengthManufacturerCountry of Origin
    CIALIS20mgMacro Pharm
    Generic CIALISMacro

    Before taking CIALIS inform your doctor if you have a medical condition (such as angina) and a lung condition known as carbon monoxide (see WARNINGS)

    CIALIS is not recommended for use if you have not drunk more than 14 units of alcohol a week.

  • Very common (seen in 1 to 10 in every 100 patients)

    % of patients report no side effects.

  • Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.

    You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.

    There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-

    • Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).

    • Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets

    for chest pain or use Rectogesic ointment?

    • Nicorandil (Ikorel), used to treat angina

    • Cimetidine, used to treat stomach or duodenal (peptic) ulcers

    • Theophylline, used to treat asthma

    • Antibiotics:- Clarithromycin, Erythromycin and Telithromycin

    • Anti-fungals such as itraconazole and ketoconazole

    • Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone

    • Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide

    • Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat

    • Recreational drugs:- amyl nitrate (poppers)

    If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.

    Read available consultation questionnaire information online for “Tadalafil at the same time as your other medications will depend on which medications you are taking.”

    You can see more information on Medication & Patient Access at:

    Scale for cardiovascular risk factors
    Medication Anderson & Bostwicket al. Brimmer et al.2011;56:1117-1130
    TadalafilSildenafil (generic Cialis)25mg, 50mg, 100mg18.9mg, 25mg, 25mg5.4mg, 1.9mg, 1.4mg19.6mg, 12.5mg, 4.6mg5.9mg, 1.9mg, 1.5mg

    See also:Premarin

    “Premarin” is the brand name for a medicine which contains the active ingredientsildenafil citrate. It is used to treat the symptoms of benign prostatic hyperplasia (BPH) and the symptoms of androgenic alopecia (a condition where there is over growth of the prostate).

    “Premarin” is a common drug treatment for androgenic alopecia.It can be taken with or without food, but it is most effective when taken at the same time as medicines for the treatment of BPH.

    There are some drug interactions which can affect the way Tadalafil works. At high doses, Tadalafil reduces its effectiveness and does not mean to work immediately.